Myelodysplastic syndrome presenting with central diabetes insipidus is associated with monosomy 7, visible or hidden: report of two cases and literature review

Abstract Background Central diabetes insipidus (CDI) is a rare complication of myelodysplastic syndrome (MDS). Although the cytogenetic features patients with MDS and CDI are not clear, in acute myeloid leukemia (AML) associated chromosome 7 and/or 3 anomalies. Case presentation In this report, we describe two concurrent CDI, one them, was first manifestation. One patient had monosomy on metaphase cytogenetics (MC). Monosomy numerous abnormalities were found other using single-nucleotide polymorphism array (SNP-A) karyotyping, while MC did uncover 7. manuscript also reviewed reported cases (DI-MDS) to summarize relationship between DI-MDS karyotype, explore best treatment strategy for DI-MDS. Conclusions closely related Allogeneic hematopoietic stem cell transplantation may be only effective The SNP-A-based karyotyping helpful reveal subtle unveil their roles clinical MDS.